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Pharmacokinetic properties (absorption, distribution, metabolism, excretion) and toxicity, referred to as ADME-tox, are also of vital importance if a compound is to be clinically useful. 18, 19 However, the potency of the compounds is not the only consideration. 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The in silico counterpart of in vitro HTS is referred to as virtual screening and aims at filtering libraries of molecules using computational methods to prioritize those most likely to be active for a given target. 10 The aim of the earliest phase in drug discovery is to identify the first hit compounds, which is sometimes attempted by high-throughput screening (HTS), the testing of many thousands of compounds with a suitable activity assay. The main purpose of CADD is to speed up and rationalize the drug design process while reducing costs. 8, 9ĬADD covers a broad range of applications spanning the drug discovery pipeline, although these are highly clustered in the early phases. 7 The crossover between computational and pharmaceutical research is typically designated computer-aided drug design (CADD). 5, 6 As with any data handling procedures, computers have become a more prominent and ubiquitous tool in drug discovery since the 1980s. 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